HIF1α is not a target of 14q deletion in clear cell renal cancer
نویسندگان
چکیده
منابع مشابه
Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.
UNLABELLED Kidney cancers often delete chromosome 3p, spanning the VHL tumor suppressor gene, and chromosome 14q, which presumably harbors ≥ 1 tumor suppressor genes. pVHL inhibits the hypoxia-inducible transcription factor (HIF), and HIF2α is a kidney cancer oncoprotein. In this article, we identify focal, homozygous deletions of the HIF1α locus on 14q in clear cell renal carcinoma cell lines....
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-74631-7